Todeschini studied at L'école supérieure d'art dramatique in Genève and after graduating in 1986, he joined the Théâtre Nanterre-Amandiers, directed by Patrice Chéreau.
He has since then been appearing on television (Les Rois maudits, 2005) and in films, many directed by Chéreau.
Todeschini has a child from a previous relationship, a son named Romain, born in 1997. He is married to actress Sophie Broustal, with whom he has a daughter, Paloma, born on 6 June 2006.
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